Occupational exposure to inhalative irritants and methacholine responsiveness
نویسندگان
چکیده
منابع مشابه
Exposure-response relationships of occupational inhalative allergens.
Only a few threshold limit values exist at present for allergens in the workplace known to cause bronchial asthma. This contrasts with the great number of occupational asthma cases observed in industrialized countries. Recently published studies provide clear evidence for exposure intensity response relationships of occupational allergens of plant, microbiological, animal or man-made origin. If...
متن کاملDissociation between airway responsiveness to methacholine and responsiveness to antigen.
Repeated aerosolized antigen challenges to brown Norway (BN) rats generate nonspecific airway hyperresponsiveness (AHR). On the other hand, some studies have demonstrated that repeated antigen challenge could attenuate antigen-specific AHR in BN rats. The authors questioned whether such dissociation in airway responses actually occurs when assessed in a single study in the same animals. The aut...
متن کاملBronchial responsiveness to methacholine in chronic bronchitis: relationship to airflow obstruction and cold air responsiveness.
The response to inhaled methacholine is increased in patients with chronic airflow obstruction, but it is not known whether this is due to true hyperresponsiveness or is a result of the airflow obstruction. In asthmatics the response to methacholine correlates with the bronchoconstriction produced by hyperventilation of cold dry air. We studied 27 patients with a history of smoking and chronic ...
متن کاملA proposed approach for setting occupational exposure limits for sensory irritants based on chemosensory models.
OBJECTIVES Setting occupational exposure limits (OELs) for odorous or irritating chemicals is a global occupational health challenge. However, often there is inadequate knowledge about the toxicology of these chemicals to set an OEL and their irritation potencies are usually not recognized until they are manufactured or used in large quantities. METHODS In this paper, the importance of accoun...
متن کاملExposure of healthy volunteers to swine house dust increases formation of leukotrienes, prostaglandin D2, and bronchial responsiveness to methacholine.
BACKGROUND Acute exposure of healthy subjects to swine house dust causes increased bronchial responsiveness to methacholine but no acute bronchoconstriction. The role of cysteinyl leukotrienes and mast cells in increased bronchial responsiveness is unclear. METHODS Ten non-asthmatic subjects were exposed to swine dust for three hours while weighing pigs in a piggery. Urine was collected prior...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Work, Environment & Health
سال: 2000
ISSN: 0355-3140,1795-990X
DOI: 10.5271/sjweh.524